Interview Questions.

Question 1. What Are The Factors Which Influence Tablet Hardness?

Answer :

Compression pressure
Binder amount (More binder greater hardness)
Moisture content
Question 2. Which Type Of Tablets Is Exempted From Disintegration Testing?

Answer :

Chewable Tablets

Pharmacology Interview Questions
Question 3. List Out The Appearance Defects Of Tables During Compression Activity?

Answer :

Capping: ‘Capping’ is the term used, whilst the upper or decrease segment of the pill separates horizontally, both in part or absolutely from the main frame of a tablet and springs off as a cap, in the course of ejection from the pill press, or at some stage in next managing.

Lamination / Laminating: ‘Lamination’ is the separation of a pill into  or greater awesome horizontal layers.

Sticking/filming: ‘Sticking’ refers back to the pill material adhering to the die wall. Filming is a gradual form of sticking and is essentially due to excess moisture inside the granulation.

Cracking: Small first-class cracks discovered at the upper and lower middle floor of the tablets, or very rarely on the side wall are called cracks.

Chipping: ‘Chipping’ is defined as the breaking of tablet edges, whilst the tablet leaves the press or throughout subsequent coping with and coating operation.

Mottling: ‘Mottling’ is the time period used to describe an unequal distribution of shade on a tablet.

Double Impression: ‘Double affect’ entails simplest the ones punches, that have a monogram or other engraving on them.

Question four. What Is The Recommended Storage Condition For Empty Hard Gelatin Capsules?

Answer :

15 - 250 C & 35 -fifty five% RH

Pharmacology Tutorial
Question 5. If Sticking Observed During Tablet Compression What May The Probable Reason For The Same?

Answer :

If the granules aren't dried properly sticking can arise.
Too little or unsuitable lubrication.
Too an awful lot binder
Hygroscopic granular
Production and Operations Management Interview Questions
Question 6. What Is The Difference Between Calibration And Validation?

Answer :

In pill production facilities, strain gradients are maintained to keep away from go infection of products through air. Usually processing regions are maintained under fine pressure with recognize to provider corridors.

Question 7. What Are The Basic Differences Between Elixir And Suspension?

Answer :

In an elixir, the lively components are mixed with a liquid, commonly a kind of syrup or alcohol, wherein they are able to dissolve.

In a suspension, the drugs is mixed with a liquid, usually water, in which it can not dissolve and therefore stays intact within the shape of small debris. The crucial component to do not forget is that you have to shake a suspension before giving each dose in order that the medicine particles are evenly disbursed at some point of the liquid.

Production and Operations Management Tutorial Quality Management Interview Questions
Question 8. What Do You Mean By Dq, Iq, Oq, & Pq?

Answer :

Design Qualification (DQ): documented verification that the proposed layout of the facilities, device, or systems is appropriate for the supposed reason.

Installation Qualification (IQ): documented verification that the gadget or structures are established or changed & observe the accepted layout of the manufacturer’s suggestions and/or consumer necessities.

Operational Qualification (OQ): documented verification that the gadget or structures are installed or changed & perform as supposed during the predicted operating stages.

Performance Qualification (PQ): documented verification that the gadget and ancillary structures are related & can carry out efficiently and reproducibly based at the approved process approach and specs.

Question 9. Write The Functions & Use Of Hvac System?

Answer :

Heating, Ventilating and Air conditioning gadget is used for temperature and humidity control inside a production surroundings. It consists of air managing units, air distribution community, air-cooling and heating gadget, air filtration, system manage system, tracking and alarm decreases

Production Planning and Control Interview Questions
Question 10. What Is Clean Room & Aseptic Area?

Answer :

Clean Room: A room in which the awareness of airborne particles is controlled to meet special airborne particulate cleanliness elegance. In addition, the concentration of microorganisms inside the surroundings is monitored; is cleanliness class defined is likewise assigned a microbial stage for air, surface, and personnel gear.

Aseptic Area: Any location in an aseptic technique gadget for which airborne particulate and microorganism tiers are controlled to particular levels appropriate to the sports performed inside that surroundings.

Quality Management Tutorial
Question eleven. Which Type Of Water Is Used In Sterile Preparation?

Answer :

Water for Injection (Bulk)-

Characters-A clear, colorless, odorless and tasteless liquid.

Nitrates-Not more than zero.2 ppm
Heavy metals-Not more than 0.1 ppm
Conductivity-Conductivity at 20°C no longer extra than 1.1 µS.Cm-1.
Microbial Contamination-Total feasible aerobic matter need to much less than 10 micro-organism in keeping with a hundred ml. Absence of E.
Coli, Salmonella, Staphylococcus aureus & Pseudomonas.
Bacterial endotoxins-Less than 0.25 IU according to ml.
Supervision Interview Questions
Question 12. What Are The Packaging Components Of Aerosol?

Answer :

Propellant
Container
Valve and actuator
Product pay attention
Pharmacology Interview Questions
Question thirteen. How Many Grams Of Dextrose Required To Prepare 4000 Ml Of eight% Solution?

Answer :

solute = 4000

x = 2 hundred g

S g. = a hundred ml   ,          

X   = 4000 ml

X = 4000 x S/one hundred = 200 g

Question 14. Peppermint Spirit Contains 10% (v/v) Of Peppermint Oil. What Volume Of Spirit Contain 75 Ml Of Active Ingredient?

Answer :

Volume in ml = seventy five/zero.1 =750 ml

Question 15. What Are The Differences Between Ointment & Cream?

Answer :

An ointment is eighty percentage oil and 20 percentage water.
A cream is 50 percentage oil and 50 percentage water.
Ointment is an emulsion of water/Oil        
A cream is an emulsion of Oil/water, Thick
Thin Ointment has very moisturizing effect, Preferable for Dry skin       
Cream has moderate in moisturizing. Preferable for moist skin
Maintenance and Manufacturing Interview Questions
Question sixteen. What S Vortex?

Answer :

In fluid dynamics, a vortex is a location within a fluid where the drift is often a spinning movement about an imaginary axis, instantly or curved.

Question 17. Write Down The Tablet Manufacturing Process?

Answer :

Wet granulation         
Dry granulation         
Direct compression
Manufacturing Industrial Engineer Interview Questions
Question 18. How Many Methods Of Sterilization Involved In Pharmaceutical Plant?

Answer :

Physical Method
Thermal (Heat) techniques
Radiation method
Filtration technique
Chemical Method
Gaseous approach
Production and Operations Management Interview Questions
Question 19. What Is Bfs Technology?

Answer :

BFS means Blow Fill Seal. This era generally used for sterilized product like ophthalmic drops, where container education, fabric fill and sealing all are occur at a time.

Question 20. What Are The Main Components Of Effervescent Tablets?

Answer :

The bubbling tablet in particular consists of 3 additives:

Active aspect
Acid source
Alkaline compound, constituted with the aid of a carbonate or bicarbonate
Pharmaceutical Quality Assurance Interview Questions
Question 21. What Is Lyophilization?

Answer :

Lyophilization, or freeze drying, there is a water is frozen, followed by means of its removal from the sample, to begin with by sublimation (primary drying) and then by means of desorption (secondary drying). In this system, the moisture content of the product is decreased to this sort of low level that does not support biological boom or chemical reactions which gives the stableness to the components. This technique useful in formula development of medication which are thermolabile and/or risky in aqueous medium.

Question 22. Define Primary And Secondary Packaging?

Answer :

The number one packaging encompass the ones packaging components that have a direct contact with the product (i.E. Bottle, cap, cap liner, label etc).

The secondary packaging specifically presents the extra physical protection necessary to undergo the secure warehousing and for fill up packaging.

Question 23. Define Strip Package And Blister Package?

Answer :

Strip packages have as a minimum one sealed pocket of material with every pocket containing a single dose of the product. The bundle is made from  layers of film or laminate cloth. The nature and stage of protection that is required through the contained product will affect the composition of those layers.

Blister applications are composed of a base layer, with cavities referred to as blisters which contain the pharmaceutical product, and a lid. This lid is sealed to the base layer by way of warmness, stress or each. They are more inflexible than strip programs and are not used for powders or semi-solids. In tropical regions blister programs with an extra aluminium membrane is used which provide more safety in opposition to high humidity.

Pharmacist Interview Questions